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Copley Scientific data analysis software
Data Analysis Software, supplied by Copley Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/Analysis+Software/analysis+data+software/pmc13279920-216-9-13
Average 86 stars, based on 1 article reviews
data analysis software - by Bioz Stars, 2026-09
86/100 stars

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Article Title: Inhaled nintedanib dry powder formulation for the treatment of idiopathic pulmonary fibrosis: Pharmacodynamic and pharmacokinetic study.
Article Snippet: Nintedanib has been clinically proven to slow the progression of idiopathic pulmonary fibrosis (IPF); however, its therapeutic utility is limited by the side effects resulting from extensive tissue distribution following oral administration.. To minimize systemic exposure and related adverse effects, an inhalable dry powder formulation of nintedanib was developed to directly deliver the drug to the lung.. The spray-dried formulation of nintedanib (SD-NTB), incorporating leucine as a dispersion enhancer, was successfully prepared, achieving favorable in vitro aerodynamic performance.

Article Title: Plasminogen-cyclodextrin aerosol for ARDS: activity retention in simulated oxygen therapy and inflammation-triggered clot lysis.
Article Snippet: Acute Respiratory Distress Syndrome (ARDS) involves intense pulmonary inflammation, endothelial damage, and fibrin accumulation, often requiring oxygen therapy.. Plasminogen (PLG), a fibrinolytic zymogen, has therapeutic potential for resolving fibrin deposits in the lungs but is vulnerable to oxidative degradation during aerosolization.. This study presents a clinically feasible inhalable formulation of PLG complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), intended to preserve enzymatic function during nebulization under oxygenrich conditions.

Article Title: Novel diffusion-dominated mixing for dry powder inhalations development: implementation and mechanistic insights.
Article Snippet: The Hummer acoustic resonance mixer (HAM) leverages high-frequency acoustic resonance to enable a novel mechanical shear-free mixing.. This mixing technology induces diffusion-dominated mixing and localized pseudoconvective particle motion, minimizing drug loss and reducing shear damage to particles.. This dual mechanism promotes efficient dispersion of micronized drug particles and ensures uniform drug-carrier adhesion, offering significant advantages for developing dry powder inhalations (DPIs).

Software:

Article Title: Inhaled nintedanib dry powder formulation for the treatment of idiopathic pulmonary fibrosis: Pharmacodynamic and pharmacokinetic study.
Article Snippet: Nintedanib has been clinically proven to slow the progression of idiopathic pulmonary fibrosis (IPF); however, its therapeutic utility is limited by the side effects resulting from extensive tissue distribution following oral administration.. To minimize systemic exposure and related adverse effects, an inhalable dry powder formulation of nintedanib was developed to directly deliver the drug to the lung.. The spray-dried formulation of nintedanib (SD-NTB), incorporating leucine as a dispersion enhancer, was successfully prepared, achieving favorable in vitro aerodynamic performance.

Article Title: The development of ciclesonide dry powder inhalation and preliminary in vivo pharmacokinetic studies in rats
Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

Article Title: Plasminogen-cyclodextrin aerosol for ARDS: activity retention in simulated oxygen therapy and inflammation-triggered clot lysis.
Article Snippet: Acute Respiratory Distress Syndrome (ARDS) involves intense pulmonary inflammation, endothelial damage, and fibrin accumulation, often requiring oxygen therapy.. Plasminogen (PLG), a fibrinolytic zymogen, has therapeutic potential for resolving fibrin deposits in the lungs but is vulnerable to oxidative degradation during aerosolization.. This study presents a clinically feasible inhalable formulation of PLG complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), intended to preserve enzymatic function during nebulization under oxygenrich conditions.

Article Title: Fucose-tobramycin sponge-like microparticles to treat pulmonary Pseudomonas aeruginosa infections in a lectin-competitive approach.
Article Snippet: .. The collected data were analyzed utilizing the Copley inhalation test data analysis software version 3.10 (Copley Scientific Ltd, Nottingham, UK), which encompassed the assessment of emitted dose (ED), fine particle fraction (FPF), and mass median aerodynamic diameter (MMAD). ..

Article Title: Factors Influencing the Dispersibility of Glycopyrronium Bromide and Indacaterol Maleate - Combined In Vitro and In Silico Study.
Article Snippet: .. Aerodynamic parameters were calculated using CITDAS (Copley Inhaler Data Analysis Software, UK, version 3.10), a commercial data‐processing software provided by Copley Scientific, Nottingham, UK. ..

Article Title: Novel diffusion-dominated mixing for dry powder inhalations development: implementation and mechanistic insights.
Article Snippet: The Hummer acoustic resonance mixer (HAM) leverages high-frequency acoustic resonance to enable a novel mechanical shear-free mixing.. This mixing technology induces diffusion-dominated mixing and localized pseudoconvective particle motion, minimizing drug loss and reducing shear damage to particles.. This dual mechanism promotes efficient dispersion of micronized drug particles and ensures uniform drug-carrier adhesion, offering significant advantages for developing dry powder inhalations (DPIs).

Article Title: Engineered Spray-Dried PLGA-PEG Dual-Coated Micelles with Lactose/Trehalose Matrices for Pulmonary Doxorubicin Delivery: Achieving Sustained Release and Improved Aerosol Performance in NSCLC Therapy
Article Snippet: inadequate tumor selectivity, and dose-dependent toxicities, most notably life-threatening cardiotoxicity and myelosuppression [2, 3].. Inhalable nanocarrier systems represent a promising strategy to overcome these limitations by leveraging the lungs as both the primary disease site and a directly accessible portal for localized therapy.. This approach aims to maximize intratumoral drug deposition while minimizing systemic exposure and associated toxicity [4, 5].

Aerosol:

Article Title: Plasminogen-cyclodextrin aerosol for ARDS: activity retention in simulated oxygen therapy and inflammation-triggered clot lysis.
Article Snippet: Acute Respiratory Distress Syndrome (ARDS) involves intense pulmonary inflammation, endothelial damage, and fibrin accumulation, often requiring oxygen therapy.. Plasminogen (PLG), a fibrinolytic zymogen, has therapeutic potential for resolving fibrin deposits in the lungs but is vulnerable to oxidative degradation during aerosolization.. This study presents a clinically feasible inhalable formulation of PLG complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), intended to preserve enzymatic function during nebulization under oxygenrich conditions.



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Image Search Results


Oxygen consumption rate (OCR) in the presence or absence of spheroids (A) Incucyte image of spheroid in the center of the microplate well at the end of the assay and (B) the corresponding OCR kinetic graph showing a response after drug injections as expected. (C) Image of a microplate well with no spheroid detected at the end of the assay and (D) corresponding OCR kinetic graph showing no response after drug injections.

Journal: STAR Protocols

Article Title: Protocol for Seahorse 3D Mito Stress assay in patient-derived atypical teratoid rhabdoid tumor CHLA-05-ATRT single neurospheres

doi: 10.1016/j.xpro.2026.104515

Figure Lengend Snippet: Oxygen consumption rate (OCR) in the presence or absence of spheroids (A) Incucyte image of spheroid in the center of the microplate well at the end of the assay and (B) the corresponding OCR kinetic graph showing a response after drug injections as expected. (C) Image of a microplate well with no spheroid detected at the end of the assay and (D) corresponding OCR kinetic graph showing no response after drug injections.

Article Snippet: Incucyte Organoid Analysis Software Module , Sartorius , 9600–0034.

Techniques:

Effect of coating timing on spheroid retention in microplate wells (A) Incucyte image of a poly-lysine coated microplate with spheroids transferred on the same day as the assay, taken before the assay. (B) Image of the same plate taken after the assay, showing that the spheroids were displaced and/or destroyed during the assay. (C) Image of a poly-lysine coated microplate with spheroids transferred the day before the assay, taken before the assay and (D) after the assay, showing that the spheroids were intact.

Journal: STAR Protocols

Article Title: Protocol for Seahorse 3D Mito Stress assay in patient-derived atypical teratoid rhabdoid tumor CHLA-05-ATRT single neurospheres

doi: 10.1016/j.xpro.2026.104515

Figure Lengend Snippet: Effect of coating timing on spheroid retention in microplate wells (A) Incucyte image of a poly-lysine coated microplate with spheroids transferred on the same day as the assay, taken before the assay. (B) Image of the same plate taken after the assay, showing that the spheroids were displaced and/or destroyed during the assay. (C) Image of a poly-lysine coated microplate with spheroids transferred the day before the assay, taken before the assay and (D) after the assay, showing that the spheroids were intact.

Article Snippet: Incucyte Organoid Analysis Software Module , Sartorius , 9600–0034.

Techniques: